We characterize a type of functional explanation that addresses why a homologous trait originating deep in the evolutionary history of a group remains widespread and largely unchanged across the group’s lineages. We argue that biologists regularly provide this type of explanation when they attribute conserved functions to phenotypic and genetic traits. The concept of conserved function applies broadly to many biological domains, and we illustrate its importance using examples of molecular sequence alignments at the intersection of evolution and cell biology. (...) We use these examples to show how the study of conserved functions can integrate knowledge of a trait’s causal effects on fitness and its history of natural selection without invoking adaptation. We also show how conserved function provides a novel basis for addressing objections against evolutionary functions raised by Robert Cummins. (shrink)

Koonin, in an article in this issue, claims that CRISPR–Cas systems are mechanisms for the inheritance of acquired adaptive characteristics, and that the operation of such systems comprises a “Lamarckian mode of evolution.” We argue that viewing the CRISPR–Cas mechanism as facilitating a form of “directed mutation” more accurately represents how the system behaves and the history of neoDarwinian thinking, and is to be preferred.

In lieu of an abstract, here is a brief excerpt of the content:Oinoe and the Painted Stoa: Ancient And Modern Misunderstandings?Jeremy G. TaylorThe argive and athenian defeat of the spartans in a battle at Argive Oinoe remains a problem for students of Greek art, Greek history, and the Periēgēsis of Pausanias.1 A painting of the battle stood in the Painted Stoa in the Athenian Agora (Paus. 1.15.1). At Delphi the Argives dedicated statues of the Seven against Thebes from the (...) spoils of victory, and statues of the Epigonoi nearby celebrated the same engagement, or so Pausanias believed (10.10.4). (See the Appendix for texts and translations.) The Stoa was erected by around 460 b.c.,2 and the sculptors of the Delphic statues, the Thebans Hypatodoros and Aristogeiton, appear to have been active in the 450s.3 Pausanias’ battle of Oinoe is therefore usually assigned to the middle of the fifth century, specifically to the period from 462, when Athens formed an alliance with Sparta’s old enemy Argos (Thuc. 1.102.4), to 451, when Athens and Sparta concluded a five–year truce (Thuc. 1.112.1).4 But a fifth–century b.c. battle, important enough to be commemorated by the Athenians in the Agora and the Argives at Delphi, yet so obscure that it is ignored by Thucydides and all surviving ancient authors except Pausanias in the second century a.d., is rightly seen as a puzzle. Moreover, the shadowy battle of Oinoe hardly seems to deserve a place alongside three other notable events depicted in the Stoa: Marathon, the Capture of Troy, and the Amazonomachy (Paus. 1.15.1–3). To take Pausanias at his word, therefore, is not an option without difficulties, and the skepticism of the [End Page 223] Cambridge Ancient History is justified: “The battle of Oinoe is not easy to believe in.”5But attempts to unravel Pausanias’ meaning raise problems of their own. One option is to amend the text. Thus for “Oinoe” read “Orneai” (Pritchett 1994), the name of a stronghold full of Argive exiles defended by a force of Lakedaimonians, which the Argives and Athenians razed to the ground in 416 (Thuc. 6.7.1–2). This suits Pausanias’ treatment of the Delphic monuments, but it remains unclear why the Athenians chose to celebrate this particular event in such a striking manner. A more popular approach is to argue that Pausanias misreported the painting. For example, the painting commemorated not Oinoe, but Oinophyta, perhaps with the local nymph Oinoe in attendance (Stier 1934). Oinophyta was certainly a famous Athenian victory, but the enemy was Boiotian not Spartan and, so far as we know, the Argives played no part (Thuc. 1.108.2–3). Alternatively, the painting celebrates a real battle at Oinoe via a mythical scene which (it is supposed) was associated with the area: the Athenians demanding the bodies of the Seven from the Thebans on behalf of the Argives (Jeffery 1965). But here again the Athenians would be squaring up to the wrong enemy. Or there is the bold suggestion of Francis and Vickers that the Oinoe painting has nothing to do with Oinoe in Argos but rather depicts the arrival of Plataian forces to join the Athenians at Marathon from the nearby Attic deme of Oinoe—and hence forms a companion piece to the Marathon painting. “We therefore imagine that the scene may have been depicted along the following lines: the Plataians are coming down the mountainside from Oinoe, in the vicinity of the Cave of Pan and perhaps beneath the gaze of Artemis Agrotera” (1985b, 103). From this perspective, though, Pausanias will have badly misread both the participants and the nature of the action.6 [End Page 224]These last three solutions suffer from the same difficulty. It is clearly unsatisfactory for us to accuse Pausanias of such a careless treatment of the Oinoe painting, while at the same time accepting down to the last detail, as most scholars do, his account of the other three pictures in the Stoa (to say nothing of his lengthy description of Polygnotos’ Sack of Troy and Nekuia in the Knidian Leschē, 10.25–31). Such carelessness is surely not characteristic of... (shrink)

This article builds on my previous article on Dirk H. Th. Vollenhoven (Ive 2015) and provides an overview of the development of the systematic philosophy of Herman Dooyeweerd. This article seeks to provide an overview of the key developments in the thinking of Dooyeweerd, both in the convergences arising from the conversation of the two brothers-in-law and long-term colleagues and in their divergences. Dooyeweerd and Vollenhoven worked within the tradition of Abraham Kuyper, the father of Reformational philosophy. The development of (...) their respective philosophical systematics has tended to be addressed separately. However, I argue that the close cooperation between the two philosophers was critical in the formulation of the philosophy of the cosmonomic Idea. The philosophical conversation between the two persisted, despite critical divergences, largely aired privately. Their respective insights remained a source of mutual stimulus and complementarity foundational for Reformational philosophy. (shrink)

Research examining firm and industry effects on performance has primarily focused on the financial aspects of firm performance. Corporate social performance is a major aspect of firm performance that has been under-examined empirically in the literature to date. Adding to the fundamental debate regarding firm versus industry effects on performance, this study uses data drawn from the Kinder, Lydenberg and Domini Co. database to examine the degree to which CSP is related to firm, industry, and temporal factors. The results of (...) these analyses suggest that CSP tends to change in a linear manner over time; however, the slope of this line varies across firms and industries. These findings are supported by several robustness checks accounting for autocorrelation, alternative measures of industry, different samples commonly used when using KLD data to measure CSP, and alternative measures of CSP when using the KLD database. The authors also directly compare firm, industry, and temporal effects between CSP and financial performance. (shrink)

The perceived support of supernatural agents has been historically, ethnographically, and theoretically linked with confidence in engaging in violent intergroup conflict. However, scant experimental investigations of such links have been reported to date, and the extant evidence derives largely from indirect laboratory methods of limited ecological validity. Here, we experimentally tested the hypothesis that perceived supernatural aid would heighten inclinations toward coalitional aggression using a realistic simulated coalitional combat paradigm: competitive team paintball. In a between-subjects design, US paintball players recruited (...) for the study were experimentally primed with thoughts of supernatural support using a guided visualization exercise analogous to prayer, or with a control visualization of a nature scene. The participants then competed in a team paintball battle game modeled after “Capture the Flag.” Immediately before and after the battle, participants completed surveys assessing confidence in their coalitional and personal battle performance. Participants assessed their coalition’s prospects of victory and performance more positively after visualizing supernatural aid. Participants primed with supernatural support also reported inflated assessments of their own performance. Importantly, however, covarying increases in assessments of their overall coalition’s performance accounted for the latter effect. This study provided support for the hypothesis that perceived supernatural support can heighten both prospective confidence in coalitional victory and retrospective confidence in the combat performance of one’s team, while highlighting the role of competitive play in evoking the coalitional psychology of intergroup conflict. These results accord with and extend convergent prior findings derived from laboratory paradigms far removed from the experience of combat. Accordingly, the field study approach utilized here shows promise as a method for investigating coalitional battle dynamics in a realistic, experientially immersive manner. (shrink)

give a proof of the existence of nonlocal influences acting on correlated spin-1/2 particles in the singlet state which does not require any particular interpretation of quantum mechanics (QM). (Except Stapp holds that the proof fails under a many-worlds interpretation of QM—a claim we analyse in 1.2.) Recently, in responding to Redhead's ([1987], pp. 90-6) criticism that the Stapp 1 proof fails under an indeterministic interpretation of QM, Stapp [1989] (henceforth Stapp 2), has revised the logical structure of his proof (...) including its crucial locality assumption. Our main aim is to show that this revision is a step in the wrong direction because it faces two difficulties which undermine the resulting proof's significance (3.1) and validity (3. 2). We also clarify and extend the Stapp 1 proof (1. 1) with the aid of Lewis' analysis of counterfactuals (1. 2) and causal dependence (2. 2 and 2. 3). In so doing, we are able to identify two new defects in the Stapp 1 proof (1. 3 and 2. 1) in addition to corroborating Redhead's criticism (2. 2). Also, the additional assumptions which save the Stapp 1 proof's validity are detailed (2. 3) and some new difficulties for the determinist are pointed out by exploiting a slightly extended version of the proof (2. 4). In providing this full analysis of the Stapp 1 proof, we also construct the necessary framework within which to provide a critique of Stapp 2's proof (3). *Portions of this paper were presented by R. K. Clifton to the 1988 British Society for the Philosophy of Science Conference at the University of Southampton. R. K. Clifton wishes to thank the Natural Sciences and Engineering Research Council of Canada, the Royal Commission for the Exhibition of 1851, and the Governing Body of Peterhouse at Cambridge University for support during this work. (shrink)

_A smart philosophical look at the cult hit television show, _Arrested Development__ _Arrested Development_ earned six Emmy awards, a Golden Globe award, critical acclaim, and a loyal cult following—and then it was canceled. Fortunately, this book steps into the void left by the show's premature demise by exploring the fascinating philosophical issues at the heart of the quirky Bluths and their comic exploits. Whether it's reflecting on Gob's self-deception or digging into Tobias's double entendres, you'll watch your favorite scenes and (...) episodes of the show in a whole new way. Takes an entertaining look at the philosophical ideas and tensions in the show's plots and themes Gives you new insights about the Bluth family and other characters: Is George Michael's crush on his cousin unnatural? Is it immoral for Lindsay to lie about stealing clothes to hide the fact that she has a job? Are the pictures really of bunkers or balls? Lets you sound super-smart as you rattle off the names of great philosophers like Sartre and Aristotle to explain key characters and episodes of the show Packed with thought-provoking insights, _Arrested Development and Philosophy_ is essential reading for anyone who wants to know more about their late, lamented TV show. And it'll keep you entertained until the long-awaited _Arrested Development_ movie finally comes out. (shrink)

ABSTRACT:This manuscript develops the concept of organizational virtue orientation (OVO) and examines differences between family and non-family firms on the six organizational virtue dimensions of Integrity, Empathy, Warmth, Courage, Conscientiousness, and Zeal. Using content analysis of shareholder letters fromS&P 500companies, our analyses find that there are significant differences between family and non-family firms in their espoused OVO, with family firms generally being higher. Specifically, family firms were significantly higher on the dimensions of Empathy, Warmth, and Zeal, but lower on Courage. (...) Based on these findings we further develop the OVO concept through the discussion of implications and areas for future research. (shrink)

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

There is evidence that problem-based learning (PBL) is an effective approach to teach team and problem-solving skills, but also to acquire content knowledge. However, there is hardly any literature about using PBL in philosophy classes. One problem is that PBL is resource intensive because a facilitator is needed for each group of students to support learning efforts and monitor group dynamics. In order to establish more PBL classes, the question is whether PBL can be provided without the need for facilitators. (...) We present a combination of five strategies—among them the collaborative argument visualization software AGORA-net—to replace facilitators. Additionally, we present evidence that these strategies are sufficient to provide a PBL experience that achieves intended learning goals in an ethics class and is satisfying for students without facilitators. (shrink)

Coarse-grain models are essential to understand the biological function of DNA molecules because the length and time scales of the sequence-dependent physical properties of DNA are often beyond the reach of experimental and all-atom computational methods. Simulating coarse-grain models of DNA, e.g. using Langevin dynamics, requires the parametrization of both potential and kinetic energy functions. Many studies have shown that the flexibility (i.e., potential energy) of a DNA molecule depends on its sequence. In contrast, little is known about the sequence-dependence (...) of DNA mass parameters required to model its kinetic energy. In this paper, an algebraic expression is derived for the kinetic energy as a function of linear and angular velocities of each DNA base parameterized by its mass, center of mass, and rotational inertia tensor. The parameters of this function are then approximated from a set of fine-grain molecular dynamics simulations representing all combinations of the four DNA base pairs AT, TA, GC, and CG, in different sequence contexts. Compatibility conditions associated with the assumption of each base being modeled as a rigid body were verified to be good approximations. The kinetic parameters were found to be significantly different between the four G, C, A, and T bases, and to not be dependent on the sequence context. This suggests that the effective kinetic parameters of a DNA base may depend only on the base itself, not on its neighbors. (shrink)

This paper investigates different modes of organizing for corporate social responsibility (CSR). Based on insights from organization theory, we theorize two ways to organize for CSR. “Complete” organization for CSR happens within businesses and depends on the availability of certain organizational elements (e.g., membership, hierarchy, rules, monitoring, and sanctioning). By contrast, “partial” organization for CSR happens when organizers do not have direct access to all these organizational elements. We discuss partial organization for CSR by analyzing how standards and cross-sector partnerships (...) make selective use of organizational elements. We maintain that an important feature of the increasing institutionalization of CSR—not only within businesses but also among non-governmental, governmental, and professional actors—is the rise of partial forms of organization. We discuss the contributions to this Special Issue in the context of our theorization of complete/partial organization for CSR and outline avenues for further research. (shrink)

We further develop a recent new proof (by Greenberger, Horne, and Zeilinger—GHZ) that local deterministic hidden-variable theories are inconsistent with certain strict correlations predicted by quantum mechanics. First, we generalize GHZ's proof so that it applies to factorable stochastic theories, theories in which apparatus hidden variables are causally relevant to measurement results, and theories in which the hidden variables evolve indeterministically prior to the particle-apparatus interactions. Then we adopt a more general measure-theoretic approach which requires that GHZ's argument be modified (...) in order to produce a valid proof. Finally, we motivate our more general proof's assumptions in a somewhat different way from previous authors in order to strengthen the implications of our proof as much as possible. After developing GHZ's proof along these lines, we then consider the analogue, for our proof, of Bohr's reply to the EPR argument, and conclude (pace GHZ) that in at least one respect (viz. that of most concern to Bohr) the proof is no more powerful than Bell's. Nevertheless, we point out some new advantages of our proof over Bell's, and over other algebraic proofs of nonlocality. And we conclude by giving a modified version of our proof that, like Bell's, does not rely on experimentally unrealizable strict correlations, but still leads to a testable “quasi-algebraic” locality inequality.“... to admit things not visible to the gross creatures that we are is, in my opinion, to show a decent humility, and not just a lamentable addiction to metaphysics.”J. S. Bell. (shrink)

From philosophy's founding fathers - Thales, Socrates, Plato... to great minds of the post-modern era - Satre, Ayer, Feyerabend... this concise new guide presents 100 of the world's most influential thinkers. Arranged from the ancient world to the present day, each philosopher's key ideas, notable works and pronouncements are encapsulated in a series of succinct biographies, accompanied by illustrations, at-a-glance fact panels and thought-provoking quotations. Philosophy: A Beginner's Guide uncovers the fundamental concepts of this fascinating discipline, explaining the diverging schools (...) of thought and revealing the universal aim of philosophy throughout the ages - to push back the boundaries of human knowledge in order to understand the fundamental nature of human existence. THE ANCIENT WORLD: Thales (c.635-c.543 BCE); Buddha (c.563-483 BCE); Confucius (c.55-479 BCE); Socrates (470-399 BCE); Plato (427-347 BCE); Aristotle (384-322 BCE). THE MIDDLE AGES: Avicenna (Ibn Sina) (980-1037); Peter Lombard (c1100-1160); Averroes (Ibn Rushd) 1126-1198); Thomas Aquinas (1225-1274); William of Ockham (1285- 1349). THE EARLY MODERN ERA: Machiavelli (1469-1527); Hobbes (1588-1679); Descartes (1596-1650); Locke (1632-1704); Voltaire (1694-1778). THE MODERN ERA: Fichte (1762-1814); G W F Hegel (1770-1831); Schopenhauer (1788-1860); Marx (1818-1883); Engels (1820-1895); Nietzsche (1844-1900); Dewy (1859-1952); Max Weber (1864-1920); Gasset (1883-1955); Heidegger (1889-1976). THE POST-MODERN ERA: Marcuse (1898-1979); Karl Popper (1902-1994); Sartre (1905-1980); Arendt (1906-1975); de Beauvoir (1908-1986); A J Ayer (1910-1989); Feyerabend (1924-1994); Rorty (1931-2007). And many more... (shrink)

The idea that the form of a word reflects information about its meaning has its roots in Platonic philosophy, and has been experimentally investigated for concrete, sensory-based properties since the early 20th century. Here, we provide evidence for an abstract property of ‘boundedness’ that introduces a systematic, iconic bias on the phonological expectations of a novel lexicon. We show that this abstract property is general across events and objects. In Experiment 1, we show that subjects are systematically more likely to (...) associate sign language signs that end with a gestural boundary with telic verbs (denoting events with temporal boundaries, e.g., die, arrive) and with count nouns (denoting objects with spatial boundaries, e.g., ball, coin). In Experiments 2–3, we show that this iconic mapping acts on conceptual representations, not on grammatical features. Specifically, the mapping does not carry over to psychological nouns (e.g. people are not more likely to associate a gestural boundary with idea than with knowledge). Although these psychological nouns are still syntactically encoded as either count or mass, they do not denote objects that are conceived of as having spatial boundaries. The mapping bias thus breaks down. Experiments 4–5 replicate these findings with a new set of stimuli. Finally, in Experiments 6–11, we explore possible extensions to a similar bias for spoken language stimuli, with mixed results. Generally, the results here suggest that ‘boundedness’ of words' referents (in space or time) has a powerful effect on intuitions regarding the form that the words should take. (shrink)

The prevailing notion that the problem of essential indexicals must be solved through the theory of meaning of attitude ascriptions is incorrect. Well-known attempts to solve the problem along those lines, e.g., the proposals of Lewis and Perry , have rested on the overly optimistic assumption that there is no limit in principle to the access one may have to the contents of someone else’s thoughts, including their knowledge. That assumption is challenged in this essay. The hazards associated with limited (...) accessibility can be and indeed must be alleviated by an epistemological theory in such a way that allows for a new nonsemantic approach to the problem. The following is an outline of the arguments in favor of this approach. In the first part, the problem of essential indexicals and the familiar corollary thesis that such indexicals are not reducible to nonindexicals is briefly reviewed. In the second part, indexical irreducibility is shown to hold for a range of explanations of theoretical rationality in addition to the basic explanations of action in which the irreducibility is typically illustrated. (shrink)

Aristotle's Politics is widely recognized as one of the classics of the history of political philosophy, and like every other such masterpiece, it is a work about which there is deep division.

BackgroundAlthough the number of reporting guidelines has grown rapidly, few have gone through an updating process. The STARD statement (Standards for Reporting Diagnostic Accuracy), published in 2003 to help improve the transparency and completeness of reporting of diagnostic accuracy studies, was recently updated in a systematic way. Here, we describe the steps taken and a justification for the changes made.ResultsA 4-member Project Team coordinated the updating process; a 14-member Steering Committee was regularly solicited by the Project Team when making critical (...) decisions. First, a review of the literature was performed to identify topics and items potentially relevant to the STARD updating process. After this, the 85 members of the STARD Group were invited to participate in two online surveys to identify items that needed to be modified, removed from, or added to the STARD checklist. Based on the results of the literature review process, 33 items were presented to the STARD Group in the online survey: 25 original items and 8 new items; 73 STARD Group members (86 %) completed the first survey, and 79 STARD Group members (93 %) completed the second survey.Then, an in-person consensus meeting was organized among the members of the Project Team and Steering Committee to develop a consensual draft version of STARD 2015. This version was piloted in three rounds among a total of 32 expert and non-expert users. Piloting mostly led to rewording of items. After this, the update was finalized. The updated STARD 2015 list now consists of 30 items. Compared to the previous version of STARD, three original items were each converted into two new items, four original items were incorporated into other items, and seven new items were added.ConclusionsAfter a systematic updating process, STARD 2015 provides an updated list of 30 essential items for reporting diagnostic accuracy studies. (shrink)

Jeremy Bentham was a British philosopher, jurist, and social reformer. He is regarded as the founder of modern utilitarianism.

We investigate the entrepreneurial opportunities and ethical dilemmas presented by technological turbulence. More specifically we investigate the line between Baumol’s [J. Polit. Econ. 98 (1990) 893] productive (e.g. innovation), unproductive (e.g. rent seeking) and destructive (e.g. criminal) entrepreneurship through three examples of Internet innovation – spam (destructive), music file sharing (unproductive), and Internet pharmacies (potentially productive). The emergence of accessible Internet technologies, under present norms, has created the potential for all three entrepreneurial activities. Because of the propensity for self-serving biases (...) and for bending the rules, the need for creativity in overcoming obstacles and overall liabilities of newness, entrepreneurs are likely to challenge established industrial morals and laws. Unlike new entrants, incumbents must abide by the currently accepted norms, and thus suffer from “liabilities of oldness”. The challenge for new entrants is to change sociopolitical legitimacy, whereas incumbents need to defend the established norms. We discuss competitive and other issues that result from technological turbulence and innovation. (shrink)

In considering the debate about the meaning of ‘disease’, the positions are generally presented as falling into two categories: naturalist, e.g., Boorse, and normativist, e.g., Engelhardt and many others. This division is too coarse, and obscures much of what is going on in this debate. I therefore propose that accounts of the meaning of ‘disease’ be assessed according to Hare’s (1997) taxonomy of evaluative terms. Such an analysis will allow us to better understand both individual positions and their inter-relationships. Most (...) importantly, it will show that it is unlikely that there is a single unique disease-concept at issue. Rather, different authors are, for the most part, considering different concepts. (shrink)

Primitivists about truth maintain that truth cannot be analysed in more fundamental terms. Defences of primitivism date back to the early years of analytic philosophy, being offered by G.E. Moore, Bertrand Russell, and Gottlob Frege. In more recent years, a number of contemporary philosophers—including Donald Davidson, Ernest Sosa, Trenton Merricks, Douglas Patterson, and Jamin Asay—have followed suit, defending their own versions of primitivism. I'll begin by offering a brief history of primitivism, situating each of these views within the landscape of (...) primitivist truth theories and detailing some of their core motivations and apparent shortcomings. To close the discussion, I'll offer a diagnosis of the prospects of primitivism, focusing on the mystery challenge, which has loomed large throughout the history of primitivist truth theories, and the methodology that should be used in evaluating primitivist (and other) truth theories going forward. (shrink)

This is a three-part study and defense of the idea of basic human equality. (This is the idea that humans are basically one another's equals, as opposed to more derivative theories of the dimensions in which we ought to be equal or the particular implications that equality might have for public policy.) Part (1) of the paper examines the very idea of basic equality and it tries to elucidate it by considering what an opponent of basic human equality (e.g. a (...) philosophical racist) might hold. It explores the idea of there being no morally significant fundamental divisions among humans (of the kind that some people insist on as between humans and others animals). Part (2) considers whether basic human equality must be based on some descriptive similarity among us (naturalistic or metaphysical); it considers the positions of a number of thinkers who have denied this. Part (3) considers John Rawls's conception of basic equality in terms of range properties. (Being in Ohio is a range property; Columbus and Cincinnati are both equally in Ohio even though even though Columbus is in the center of the state, while Cincinnati is just over the river from Kentucky.) It explores the application of this Rawlsian idea to the descriptive properties that might be thought relevant to human equality. This three part paper is a rather technical philosophical exploration. And it is just a beginning; we need much more work on the idea of basic equality. Some of the energy that has gone into discussions of equality as a policy aim (e.g. in the Dworkin/Sen literature or in the literature surrounding Rawls's Difference Principle) needs to be devoted to this more fundamental conception. (shrink)

It is plausible to suppose that the normativity of evaluative (e.g., moral and epistemic) judgments arises out of and is, in some sense, dependent on our actual evaluative practice. At the same time, though, it seems likely that the correctness of evaluative judgments is not merely a matter of what the underlying practice endorses and condemns; denial of this leads one into a rather objectionable form of relativism. In this paper, I will explore a social practice account of normativity according (...) to which normativity is grounded in our actual social practice of evaluation. I will show how this account allows normativity to be dependent on our actual evaluative practice, while allowing the correctness of evaluative judgments to be independent of this practice in important ways, and how the resulting temporal logic of reasons gives us a conception of morality and other sorts of evaluative discourse that is not historically local. (shrink)

We analyze the pointwise convergence of a sequence of computable elements of L1 in terms of algorithmic randomness. We consider two ways of expressing the dominated convergence theorem and show that, over the base theory RCA0, each is equivalent to the assertion that every Gδ subset of Cantor space with positive measure has an element. This last statement is, in turn, equivalent to weak weak Königʼs lemma relativized to the Turing jump of any set. It is also equivalent to the (...) conjunction of the statement asserting the existence of a 2-random relative to any given set and the principle of Σ2 collection. (shrink)

Physicians place significant weight on the distinction between acts and omissions. Most believe that autonomous refusals for procedures, such as blood transfusions and resuscitation, ought to be respected, but they feel no similar obligation to accede to requests for treatment that will, in the physician’s opinion, harm the patient (e.g., assisted death). Thus, there is an asymmetry. In this paper, we challenge the strength of this distinction by arguing that the ordering of values should be the same in both cases. (...) The reason for respecting refusals is that, in such cases, autonomy outweighs well-being. We argue that the same should be true in request cases, which means that requests should not be denied only due to the treatment being too harmful in the physician’s opinion. Our strategy is to consider and reject a number of arguments for the asymmetrical view, including an appeal to the doing–allowing distinction and positive and negative rights. The duty to respect refusals is still greater than the duty to grant requests on our view, but, by arguing that the ordering of values is the same in both cases, we show that there is less of a distinction in healthcare between requests and refusals than many currently believe. (shrink)

This article is an investigation into G. E. M. Anscombe's suggestion that there can be cases where belief takes a personal object, through an examination of the role that the activity of teaching plays in Anscombe's discussion. By contrasting various kinds of ‘teachers’ that feature in her discussion, it is argued that the best way of understanding the idea of believing someone personally is to situate the relevant encounter within the social, conversational framework of ‘engaged reasoning’. Key features of this (...) framework are highlighted, and are used to characterise the distinctive kind of teaching and learning germane to Anscombe's suggestion. (shrink)

Classicists have long been wary of comparisons, partly for ideological reasons related to the incomparability of ‘the Classical’, partly because of the often problematic basis and limited illumination afforded by such efforts as have been made: the -reception of the work of the Cambridge ritualists — such as J.G. Frazer and Jane Harrison — is a case in point in both respects. Interestingly, even the specifically comparative interests of the much more rigorous projects of the Paris School, at the Centre (...) Louis Gernet, have not had much resonance outside France, notwithstanding the enormous influence of their work concerning purely Greek subject matter. In part, perhaps, this was a result of the shift from Vernant's originally Marxist framework, in which societies were comparable in terms of an evolutionary sociological scheme, to a structuralist one, entailing an emphasis on the uniqueness of different cultural traditions. The emphasis on the uniqueness of the Classical world was only reinforced by post-structuralism and post-modernism, which in their strongest forms suggested that cultures, like languages, were fundamentally incommensurable, and thus not accessible to outsider knowledge, let alone comparable. Indeed, so virulent was the post-structuralist virus that disciplines to which we might have expected to be able to turn for guidance, like comparative religion, are only now recovering the courage ‘to compare religious phenomena, theologies or artefacts outside of footnotes or less heavily policed epilogues’. (shrink)

BackgroundCritical public health measures implemented to mitigate the spread of the novel coronavirus disease (COVID-19) pandemic have disrupted health research worldwide, including HIV prevention research. While general guidance has been issued for the responsible conduct of research in these challenging circumstances, the contours of the dueling COVID-19 and HIV/aids pandemics raise some critical ethical issues for HIV prevention research. In this paper, we use the recently updated HIV Prevention Trials Network (HPTN) Ethics Guidance Document (EGD) to situate and analyze key (...) ethical challenges related to the conduct of HIV prevention research during the COVID-19 pandemic as well as identify potential areas for refinement of the guidance document based on this unprecedented state of affairs.Main bodyNecessary actions taken for HIV prevention research studies due to the COVID-19 pandemic involve an array of ethical issues including those related to: (1) risk mitigation; (2) behavior change; (3) compounding vulnerability; (4) community engagement; (5) trial reopening; and 6) shifting research priorities.ConclusionsIn the context of the dueling HIV and COVID-19 global pandemics, research teams and sponsors must be nimble in responding to the rapidly changing environment by being sensitive to the associated ethical issues. The HTPN EGD provides a rich set of tools to help identify, analyze and address many of these issues. At the same time, future refinements of the HPTN EGD and other research ethics guidance could be strengthened by providing explicit advice regarding the ethical issues associated with disrupted research and the reopening of studies. In addition, additional consideration should be given to appropriately balancing domains of risk (e.g., physical versus social), addressing the vulnerability of research staff and community partners, and responding to un-anticipatable ancillary care needs of participants and communities. Appropriately addressing these issues will necessitate conceptual work, which would benefit from the careful documentation of the actual ethical issues encountered in research, the strategies implemented to overcome them, and their success in doing so. Throughout all of these efforts, it is critical to remember that the HIV pandemic not be forgotten in the rush to deal with the COVID-19 pandemic. (shrink)

Many naturalistically-minded philosophers want to accomplish a naturalistic reduction of normative (e.g. moral and epistemic) claims. Mindful of avoiding the naturalistic fallacy, such philosophers claim that they are not reducing moral and epistemic concepts or definitions. Rather, they are only reducing the extension of these normative terms, while admitting that the concepts possess a normative content that cannot be naturalistically reduced. But these philosophers run into a serious problem. I will argue that normative claims possess two dimensions of normativity. I (...) will further argue that certain of the reductionist’s commitments require that these two dimensions of normativity be given a naturalistic reduction, while the other of the reductionist’s commitments make such a reduction impossible. Thus, the reductionist’s commitments both require and forbid a reductionist account of morality and epistemology. Thus, as we will see, reductionism is torn between two incompatible requirements, and must fail. (shrink)

An efficient variant of the double-negation translation explains the relationship between Shoenfield’s and G¨odel’s versions of the Dialectica interpretation.